How to use
It is recommended in case of risk of digestive disorders, during digestive disorders, or during recovery from digestive disorders (diarrhea). It is recommended to use up to 25g I-Guard® per 1L of milk replacer and up to first 2 weeks of suckling. To stop diarrhea, use max 50g I-Guard® per 1L of water replacing 1-2 meals of milk replacer up to 2-3 days followed by gradual introduction of full milk replacement meals using 25g I-Guard® per 1L and up to 1 week treatment.
Recommended time of usage: 1-7 days.*
*Please take the advice of a Nutrition expert or your Vet.
The gastrointestinal (GI) tract comprises an extensive interface between an organism’s internal and external environments it is responsible for various functions including nutrient digestion and absorption, hormone production and it plays a primary role as a physical barrier between the luminal content of the GI tract and internal, sterile, tissues. As a selective barrier with a primary goal of facilitating nutrient and water absorption, the GI tract must also prevent the entry of harmful substances and organisms, while also preventing the water loss and beneficial solutes (ions, macromolecules etc.). The integrity of this barrier and the resulting permeability is influenced by numerous factors, one of them being inflammation. Over 50% of calf mortality in the first stages of life is due to diarrhea. Cryptosporidium parvum is among the primary causative factors of this disease.¹ Pathogens and toxins weaken and kill the gut lining and cells along the villi and villi-associated proteins that act as a barrier to keep bacteria out. Diarrhea contributes to calf morbidity, nutrient malabsorption, and poor production performance.² Diarrhea is triggered by inadequate absorption of nutrients as a result of overfeeding ingredients that are hard to digest or not well absorbed. This is often seen during cold weather when calves need more nutrients and instead of adding additional feedings of milk replacer, calves are fed more milk replacer but still only twice per day. Diarrhea treatment mostly focuses on replacement of lost fluids with electrolytes and re-establishment of acid-base balance within the digestive tract. Most of the cases can be well controlled under preventive management practices. Studies showed that Glucagon-like peptide 2 (GLP2), a pleiotropic hormone, has a prophylactic effect on the gastrointestinal tract of calves. GLP2 actions related to the regulation of energy absorption and maintenance of mucosal morphology, function and integrity of the intestine.³ GLP2 is released in response to stimulation by luminal nutrients, such as glucose, fatty acids and dietary fibre.⁴
